Celebrex

The active substance celecoxib is used in irritation of joint wear (so-called activated arthrosis) as well as in joint inflammation (so-called chronic polyarthritis of the group of inflammatory rheumatic diseases) to relieve pain and reduce inflammatory stimuli. Celecoxib can also be used to alleviate the symptoms of inflammatory spinal column disease Bechterew.

What is the purpose of this ingredient?

  1.     Reduce symptoms of joint wear
  2.     Reduce symptoms of arthritis (polyarthritis)
  3.     Reduce joint irritation
  4.     Reduce symptoms of inflammatory spinal disease (Bechterew’s disease)

This is how Celecoxib works

Below you will learn more about the fields of application and the mode of action of celecoxib.

Please also read the information on the drug classes non-steroidal anti-inflammatory drugs, anti-inflammatory drugs, painkillers to which the active ingredient celecoxib belongs.

Areas of application of the active substance celecoxib

The active substance celecoxib is used in irritation of joint wear (so-called activated arthrosis) as well as in joint inflammation (so-called chronic polyarthritis of the group of inflammatory rheumatic diseases) to relieve pain and reduce inflammatory stimuli. Celecoxib can also be used to alleviate the symptoms of inflammatory spinal column disease Bechterew.

For the following application areas of Celecoxib , in-depth information is available:

  •     arthritis;
  •     inflammatory rheumatic diseases.

Mode of action of celecoxib

Celecoxib belongs to the group of non-steroidal anti-inflammatory drugs and belongs to the subgroup of selective (targeted) cyclooxigenase-2 inhibitors.

The cyclooxygenases are enzymes that, inter alia, initiate the formation of certain endogenous messengers, the prostaglandins. Most prostaglandins are involved in the development of inflammation and pain. If prostaglandin formation fails by inhibition of cyclooxygenase, inflammation will regress and pain will be alleviated.

But there are also prostaglandins that exert protective functions in the body. These are important, for example, to protect the gastric mucosa from harmful substances. Such prostaglandins are produced by the enzyme cyclooxigenase-1.

Drugs like most non-steroidal anti-inflammatory drugs, which inhibit both cyclooxigenase-1 and cyclooxigenase-2, relieve pain but also cause gastric ulcers, for example. The targeted cyclooxigenase-2 inhibitors, which include celecoxib, have virtually no side effect.